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Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

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While paracellular transmigration involves passage through intercellular junctionsoften exacerbated by disrupted tight junctions under pathological conditionstranscellular transport is facilitated by various endocytic mechanisms, such as clathrin-mediated endocytosis, macropinocytosis, and lipid raft-dependent pathways 157,158,159,160,161

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